Projecte matriculat

Títol: Morphogenetic signaling propagation in a heterotypic assembloid

---

Tutor/a o Cotutor/a: PRATS SOLER, CLARA

Departament: FIS

Títol: Morphogenetic signaling propagation in a heterotypic assembloid

Data inici oferta: 21-01-2025      Data finalització oferta: 31-01-2025

---

Estudis d'assignació del projecte:

GR ENG SIS BIOLÒG 23

Lloc de realització:

UPC      Departament/centre: Departament de Física, EPSEB

Segon tutor/a extern: DAVID ORIOLA SANTANDREU (UPC)

Paraules clau:
Cell differentiation, 3D tissue patterning, computational model, reaction-diffusion, signaling propagation

Descripció del contingut i pla d'activitats:
Cells in a developing embryo communicate with their neighbors to orchestrate differentiation and tissue patterning. The mechanisms by which morphogenetic signals propagate through 3D tissues are complex, as cells not only exchange signaling molecules but also actively move within the tissue. In this study, we focus on the spatiotemporal dynamics of the T-box transcription factor Brachyury/T (Bra/T), a key mesodermal marker during anteroposterior axis formation in embryos. We investigate signaling propagation in vitro in a heterotypic assembloid, formed by fusing Bra/T+ and a Bra/T- tissue spheroids. We analyze how Bra/T signaling is transduced from the Bra/T+ tissue to the Bra/T- tissue and propose a simple reaction-diffusion model to account for the experimental observations. Finally, we explore how signaling propagation is affected by the size of the 3D tissue spheroids.

Orientació a l'estudiant: Coneixements de biologia, biofísica i programació

---